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Trometamol or Tromethamine or Tris Buffer or Tris(hydroxymethyl)aminomethane BP Ph Eur USP Grade Manufacturers
Anmol Chemicals is a manufacturer supplier exporter of Trometamol or Tromethamine or Tris Buffer or Tris(hydroxymethyl)aminomethane and it offers materials as per IP BP EP Ph Eur USP NF JP FCC Food Grade as per the the latest monograph at best prices. Anmol Chemicals Group, established in 1976, is the pioneer manufacturer of Specialty Chemicals, Pharmaceutical Excipients, Some API, Food Chemicals in India. Anmol Chemicals Group has manufacturing facilities spread across Western India, representatives in Houston, Chicago USA and Dubai, UAE. We also have toll manufacturing units for processing chemicals in a few countries around the world. We make IP, BP, EP, USP, NF, Ph. Eur., JP, FCC or Food Grade, Analytical Reagent Grade, LR or Laboratory Reagent Grades and Pure Grades of various chemicals. All our items are analyzed to meet the required standards. We can supply the product in grams for your laboratory trial and in tons for your plant scale jobs.
We manufacture Bulk Drugs / API, Excipients, Pharmaceuticals (IP BP USP NF Ph Eur EP JP), Specialty Chemicals (Pure/Reagent), Mineral Fortifiers (FCC). Our manufacturing facility is FDA approved and GLP, cGMP, ISO9001, ISO14001, ISO/IEC 17025, ISO22000, FSSC 22000, ISO45001, FSSAI, Kosher, HALAL, COPP, WHO-GMP certified and Written Confirmation (WC) is available. Solid materials can be customized for particle size, shape, and bulk density. We observe WHO Good Manufacturing Practices and Good Laboratory Practices. We are a government-recognized STAR Export House and "Authorised Economic Operator (AEO)" per Indian Customs.
All technical documents and DMF support available.
Trometamol or Tromethamine SDS of Manufacturers
Synonyms: Trometamol or Tromethamine or Tris Buffer or Tris(hydroxymethyl)aminomethane or Tris (Hydroxymethyl) Aminomethane or 2-Amino-2-(hydroxymethyl)-1,3-propanediol or THAM
CAS Number: 77-86-1, Molecular Weight: 121.14, Chemical Formula: C4H11NO3 or NH2C(CH2OH)3, EINECS EC Number: 201-064-4, FEMA: ----,
Tromethamine USP Grade Specifications:
C4H11NO3 --- 121.14
1,3-Propanediol, 2-amino-2-(hydroxymethyl)-;
2-Amino-2-(hydroxymethyl)-1,3-propanediol CAS 77-86-1
UNII: 023C2WHX2V
DEFINITION
Tromethamine contains NLT 99.0% and NMT 101.0% of tromethamine (C4H11NO3), calculated on the dried basis.
IDENTIFICATION
A. Infrared Absorption
B.
Sample solution: 1 in 5
Analysis: To 4.5 mL of a saturated solution of salicylaldehyde add 0.5 mL of glacial acetic acid, and mix. Add 4.0 mL of the Sample solution, and mix.
Acceptance criteria: A yellow color is produced.
C.
Sample solution: 1 in 5
Analysis: To 0.5 mL of a solution (4 in 10) of ceric ammonium nitrate in 2 N nitric acid add 3 mL of water and 0.5 mL of the Sample solution, and mix.
Acceptance criteria: The color changes from light yellow to orange.
Residue on Ignition: NMT 0.1%
Melting Range or Temperature: 168C to 172C
pH:
Sample solution: 1 in 20
Acceptance criteria: 10.0 to 11.5
Loss on Drying:
Analysis: Dry at 105C for 3 h.
Acceptance criteria: NMT 1.0%
Trometamol BP Ph Eur Grade Specifications:
C4H11NO3 --- 121.1 --- CAS 77-86-1
Action and use: Organic amine proton acceptor; alkalinizing agent.
DEFINITION
Trometamol contains not less than 99.0 per cent and not more than the equivalent of 100.5 per cent of aminomethylidynetri(methanol), calculated with reference to the dried substance.
CHARACTERS
A white or almost white, crystalline powder, or colourless crystals, freely soluble in water, sparingly soluble in alcohol, very slightly soluble in ethyl acetate.
IDENTIFICATION
First identification: B, C
Second identification: A, B, D
A. Solution S is strongly alkaline.
B. Melting point: 168C to 174C.
C. Infrared absorption spectrophotometry.
D. Examine the chromatograms obtained in the test for related substances. The principal spot in the chromatogram obtained with test solution (b) is similar in position, colour and size to the principal spot in the chromatogram obtained with reference solution (a).
TESTS
Solution S: Dissolve 2.5 g in carbon dioxide-free water and dilute to 50 mL with the same solvent.
Appearance of solution: Solution S is clear and colourless.
pH: The pH of freshly prepared solution S is 10.0 to 11.5.
Related substances: By thin-layer chromatography, to pass the test.
Chlorides: To 10 mL of solution S add 2.5 mL of dilute nitric acid and dilute to 15 mL with water. The solution complies with the limit test for chlorides (100 ppm).
Iron: Dissolve 1.0 g in water and dilute to 10 mL with the same solvent. The solution complies with the limit test for iron (10 ppm).
Loss on drying: Not more than 0.5 per cent, determined on 1.000 g by drying in an oven at 105C.
Sulfated ash: Not more than 0.1 per cent, determined on 1.0 g.
Bacterial endotoxins: Less than 0.03 IU/mg, if intended for use in the manufacture of parenteral preparations without a further appropriate procedure for the removal of bacterial endotoxins.
Keywords: Trometamol or Tromethamine or Tris Buffer or Tris(hydroxymethyl)aminomethane IP BP Ph Eur EP USP Analytical Reagent FCC Food Grade CAS Number 77-86-1 Manufacturer Supplier Exporter Monograph Uses Chemical Molecular Formula Weight.
Manufacturer Supplier Exporter
ANMOL CHEMICALS
Now maturing as Anmol Chemicals Private Limited
Representatives in Houston, Chicago and New York, USA
TEL: (OFF) +91 22 23726950, +91 22 23774610, +91 22 23723564
Taloja Navi Mumbai, INDIA
e-mail: info@anmol.org
Copyright and Usual Disclaimer is Applicable
Last updated
15-oct-24
Exporters to USA, Canada, UAE, Kuwait, Qatar, Gautemala, Tunisia, Europe, South Africa, Bangladesh, Sri Lanka, Tanzania, Kenya, Egypt, Iraq, Turkey, Israel, Vietnam, Nigeria, Uganda, Brazil, Chile, Argentina, Dubai, UAE, Saudi Arabia, Cameroon, Mexico, Brazil, Chile, Argentina, Korea, Thailand, Malaysia, Indonesia, Jakarta, Australia, China, Germany, France, etc.
Representatives in New York, Houston - Texas, Chicago - Illinois, Los Angeles.
All products are Sold for Industrial and Laboratory Use only. No other use is permitted.
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Tromethamine
Trometamol or Tris Buffer or Tris(hydroxymethyl)aminomethane or Tris (Hydroxymethyl) BP Ph Eur USP Grades Manufacturers