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Saccharin Sodium USP BP Ph Eur IP FCC Food Grade Manufacturers

Anmol Chemicals is a manufacturer supplier exporter of Saccharin Sodium and it offers materials as per IP BP EP Ph Eur USP NF JP FCC Food Grade as per the the latest monograph at best prices. Anmol Chemicals Group, established in 1976, is the pioneer manufacturer of Specialty Chemicals, Pharmaceutical Excipients, Some API, Food Chemicals in India. Anmol Chemicals Group has manufacturing facilities spread across Western India, representatives in Houston, Chicago USA and Dubai, UAE. We also have toll manufacturing units for processing chemicals in a few countries around the world. We make IP, BP, EP, USP, NF, Ph. Eur., JP, FCC or Food Grade, Analytical Reagent Grade, LR or Laboratory Reagent Grades and Pure Grades of various chemicals. All our items are analyzed to meet the required standards. We can supply the product in grams for your laboratory trial and in tons for your plant scale jobs.

We manufacture Bulk Drugs / API, Excipients, Pharmaceuticals (IP BP USP NF Ph Eur EP JP), Specialty Chemicals (Pure/Reagent), Mineral Fortifiers (FCC). Our manufacturing facility is FDA approved and GLP, cGMP, ISO9001, ISO14001, ISO/IEC 17025, ISO22000, FSSC 22000, ISO45001, FSSAI, Kosher, HALAL, COPP, WHO-GMP certified and Written Confirmation (WC) is available. Solid materials can be customized for particle size, shape, and bulk density. We observe WHO Good Manufacturing Practices and Good Laboratory Practices. We are a government-recognized STAR Export House and "Authorised Economic Operator (AEO)" per Indian Customs.

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Saccharin Sodium SDS of Manufacturers

Saccharin Sodium Manufacturers

Synonyms: Saccharin Sodium, Saccharin Soluble
CAS Number: 82385-42-0, Molecular Weight: 205.17 (anhydrous), Chemical Formula: C7H4NNaO3S-xH2O, EINECS EC Number: 204-886-1, FEMA: ----,

Specifications of Saccharin Sodium USP Grade:
C7H4NNaO3S-2H2O --- 241.20
C7H4NNaO3S --- 205.17
1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide, ;sodium salt, dihydrate;
1,2-Benzisothiazolin-3-one 1,1-dioxide sodium salt dihydrate CAS 6155-57-3.
Anhydrous CAS 128-44-9.

DEFINITION
Saccharin Sodium contains NLT 99.0% and NMT 101.0% of saccharin sodium (C7H4NNaO3S), calculated on the anhydrous basis.

IDENTIFICATION
A. Infrared Absorption.
B. Procedure:
Sample solution: 100 mg/mL
Potassium pyroantimonate solution: Dissolve 2 g of potassium pyroantimonate in 95 mL of hot water. Cool quickly and add 50 mL of a potassium hydroxide solution (50 mg/mL) and 1 mL of sodium hydroxide solution (8.5 in 100). Allow to stand for 24 h, filter, and dilute with water to 150 mL.
Analysis: To 10 mL of the Sample solution add 2 mL of 15% potassium carbonate, and heat to boiling. No precipitate is formed. Add 4 mL of Potassium pyroantimonate solution, and heat to boiling. Allow to cool in ice water and, if necessary, rub the inside of the test tube with a glass rod.
Acceptance criteria: A dense precipitate is formed.
C. Sodium salts impart an intense yellow color to a nonluminous flame.

ASSAY
Procedure:
Sample solution: Dissolve 150 mg of Saccharin Sodium in 50 mL of glacial acetic acid. [Note: Slight heating may be needed to dissolve the sample.]
Analysis: Titrate the Sample solution with 0.1 N perchloric acid, determining the endpoint potentiometrically. Perform a blank determination and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 20.52 mg of saccharin sodium (C7H4NNaO3S).
Acceptance criteria: 99.0%–101.0% on the anhydrous basis

Limit of Toluenesulfonamides: to pass the test by Chromatography.
Acceptance criteria: If any peaks due to o-toluenesulfonamide and p-toluenesulfonamide appear in the chromatogram of the Sample solution, the ratio of their areas to that of caffeine (internal standard) is NMT the corresponding ratio in the chromatogram of the Standard solution.
Individual impurities:
o-Toluenesulfonamide: 10 ppm.
p-Toluenesulfonamide: 10 ppm.
Limit of Benzoate and Salicylate:
Sample solution: 50 mg/mL
Analysis: To 10 mL of the Sample solution add 5 drops of 6 N acetic acid, and then add 3 drops of ferric chloride.
Acceptance criteria: No precipitate or violet color appears.
Water Determination: NMT 15.0%
Readily Carbonizable Substances: To pass the test.
Acidity or Alkalinity:
Sample solution: 100 mg/mL in carbon dioxide-free water
Analysis: To 10 mL of the Sample solution add 1 drop of PhPh.
Acceptance criteria: No red or pink color is produced. Then add 1 drop of 0.1 N sodium hydroxide: a red or pink color is produced.
Clarity of Solution: To pass the test.
Acceptance criteria: The Sample solution shows the same clarity as that of water, or its opalescence is NMT that of Reference suspension.
Color of Solution: To pass the test.
Acceptance criteria: The ;Sample solution has the appearance of water or is not more intensely colored than the Standard solution.
Packaging and Storage: Preserve in well-closed containers. Store at room temperature.
Labeling: Where the quantity of saccharin sodium is indicated in the labeling of any preparation containing Saccharin Sodium, this shall be expressed in terms of saccharin C7H5NO3S).

Saccharin Sodium BP Ph Eur Grade Specifications
Soluble Saccharin
Ph Eur
C7H4NNaO3S -- 205.2 CAS 128-44-9
Action and use: Sweetening agent.

DEFINITION
2-Sodio-1,2-benzisothiazol-3(2H)-one 1,1-dioxide.
Content: 99.0 per cent to 101.0 per cent (anhydrous substance). It may contain a variable quantity of water.

CHARACTERS
Appearance: White or almost white, crystalline powder or colourless crystals, efflorescent in dry air.
Solubility: Freely soluble in water, sparingly soluble in ethanol (96 per cent).

IDENTIFICATION
First identificationiB, E.
Second identificationiA, C, D, E.
A. Melting point: 226C to 230C.
To 5 ml of solution S (see Tests) add 3 ml of dilute hydrochloric acid. A white precipitate is formed. Filter and wash with water. Dry the precipitate at 100-105C.
B. Infrared absorption spectrophotometry.
C. Mix about 10 mg with about 10 mg of resorcinol, add 0.25 ml of sulphuric acid and carefully heat the mixture over a naked flame until a dark green colour is produced. Allow to cool, add 10 ml of water and dilute sodium hydroxide solution until an alkaline reaction is produced. An intense green fluorescence develops.
D. To 0.2 g add 1.5 ml of dilute sodium hydroxide solution, evaporate to dryness and heat the residue carefully until it melts, avoiding carbonisation. Allow to cool, dissolve the mass in about 5 ml of water, add dilute hydrochloric acid until a weak acid reaction is produced and filter, if necessary. To the filtrate add 0.2 ml of ferric chloride solution. A violet colour develops.
E. Solution S gives reaction (a) of sodium.

TESTS
Solution S: Dissolve 5.0 g in carbon dioxide-free water and dilute to 50.0 ml with the same solvent.
Appearance of solution: The solution is clear and colourless.
Dissolve 5.0 g in 25 ml of carbon dioxide-free water.
Acidity or alkalinity: To 10 ml of solution S add about 0.05 ml of a 10 g/l solution of PhPh in ethanol (96 per cent). The solution is not pink. Add 0.1 ml of sodium hydroxide 0.1 M. The solution becomes pink.
o- and p-Toluenesulphonamide: Gas chromatography to pass the test.
Readily carbonisable substances: Dissolve 0.20 g in 5 ml of sulphuric acid and keep at 48-50C for 10 min. When viewed against a white background, the solution is not more intensely coloured than a solution prepared by mixing 0.1 ml of red primary solution, 0.1 ml of blue primary solution and 0.4 ml of yellow primary solution with 4.4 ml of water.
Heavy metals: Maximum 20 ppm.
Water: Maximum 15.0 per cent, determined on 0.200 g.

ASSAY
Dissolve 0.150 g in 50 ml of anhydrous acetic acid, with slight heating if necessary. Titrate with 0.1 M perchloric acid, determining the end-point potentiometrically. Carry out a blank titration. 1 ml of 0.1 M perchloric acid is equivalent to 20.52 mg of C7H4NNaO3S.

STORAGE
In an airtight container.

Sodium Saccharin FCC Food Grade Specifications
1,2-Benzisothiazole-3(2H)-one 1,1-Dioxide Sodium Salt;
Sodium o-Benzosulfimide; Soluble Saccharin
C7H4NNaO3S-2H2O --- Formula weight 241.19
INS: 954 CAS 128-44-9

DESCRIPTION
Sodium Saccharin occurs as white crystals or as a white, crystalline powder. In powdered form, it effloresces to the extent that it usually contains only about one-third the amount of water indicated in its molecular formula. One gram is soluble in 1.5 mL of water and in about 50 mL of alcohol.
Function: Nonnutritive sweetener.

REQUIREMENTS
Identification:
A. Dissolve about 100 mg of sample in 5 mL of a 1:20 solution of sodium hydroxide, evaporate to dryness, and gently fuse the residue over a small flame until ammonia no longer evolves. After the residue has cooled, dissolve it in 20 mL of water, neutralize the solution with 2.7 N hydrochloric acid, and filter. Add 1 drop of ferric chloride to the filtrate. A violet color appears.
B. Mix 20 mg of sample with 40 mg of resorcinol, cautiously add 10 drops of sulfuric acid, and heat the mixture in a liquid bath at 200C for 3 min. After cooling, add 10 mL of water and an excess of 1 N sodium hydroxide. A fluorescent green liquid results.
C. The residue obtained by igniting a 2-g sample gives positive tests for Sodium.
D. Add 1 mL of hydrochloric acid to 10 mL of a 1:10 aqueous solution. A crystalline precipitate of saccharin forms. Wash the precipitate well with cold water, and dry at 105C for 2 h. The saccharin thus obtained melts between 226C and 230C.
Assay: Not less than 98.0% and not more than 101.0% of C7H4NNaO3S, calculated on the anhydrous basis.
Alkalinity: Passes test.
Benzoate and Salicylate: Passes test.
Lead: Not more than 2 mg/kg.
Readily Carbonizable: Substances Passes test.
Selenium: Not more than 0.003%.
Toluenesulfonamides: Not more than 0.0025%.
Water: Not more than 15.0%.

Keywords: Saccharin Sodium, Saccharin Soluble IP BP Ph Eur EP USP Analytical Reagent FCC Food Grade Manufacturer Supplier Exporter Monograph Uses Chemical Molecular Formula Weight.

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Manufacturers

ANMOL CHEMICALS
Now maturing as Anmol Chemicals Private Limited
Representatives in Houston, Chicago and New York, USA
TEL: (OFF) +91 22 23726950, +91 22 23774610, +91 22 23723564
Taloja Navi Mumbai, INDIA

e-mail: info@anmol.org

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Last updated 11-feb-24

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Saccharin Sodium
IP BP Ph Eur USP FCC Food Grades Manufacturers
Saccharin Sodium