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Magnesium Pidolate BP Ph Eur EP IP Grade Manufacturers
Anmol Chemicals is a manufacturer supplier exporter of Magnesium Pidolate and it offers materials as per IP BP EP Ph Eur USP NF JP FCC Food Grade as per the the latest monograph at best prices. Anmol Chemicals Group, established in 1976, is the pioneer manufacturer of Specialty Chemicals, Pharmaceutical Excipients, Some API, Food Chemicals in India. Anmol Chemicals Group has manufacturing facilities spread across Western India, representatives in Houston, Chicago USA and Dubai, UAE. We also have toll manufacturing units for processing chemicals in a few countries around the world. We make IP, BP, EP, USP, NF, Ph. Eur., JP, FCC or Food Grade, Analytical Reagent Grade, LR or Laboratory Reagent Grades and Pure Grades of various chemicals. All our items are analyzed to meet the required standards. We can supply the product in grams for your laboratory trial and in tons for your plant scale jobs.
We manufacture Bulk Drugs / API, Excipients, Pharmaceuticals (IP BP USP NF Ph Eur EP JP), Specialty Chemicals (Pure/Reagent), Mineral Fortifiers (FCC). Our manufacturing facility is FDA approved and GLP, cGMP, ISO9001, ISO14001, ISO/IEC 17025, ISO22000, FSSC 22000, ISO45001, FSSAI, Kosher, HALAL, COPP, WHO-GMP certified and Written Confirmation (WC) is available. Solid materials can be customized for particle size, shape, and bulk density. We observe WHO Good Manufacturing Practices and Good Laboratory Practices. We are a government-recognized STAR Export House and "Authorised Economic Operator (AEO)" per Indian Customs.
All technical documents and DMF support available.
Magnesium Pidolate SDS of Manufacturers
Synonyms: Magnesium salt of pidolic acid, Pyroglutamic acid
CAS Number: 62003-27-4, Molecular Weight: 280.5, Chemical Formula: C10H12N2O6Mg, EINECS EC Number: 263-365-7, FEMA: ----,
Magnesium Pidolate BP Ph Eur Grade Specifications
Ph Eur
C10H12N2O6Mg -- 280.5 -- CAS 62003-27-4
DEFINITION
Magnesium bis[(2S)-5-oxopyrrolidine-2-carboxylate].
Content: 8.49 per cent to 8.84 per cent of Mg (Ar = 24.31) (anhydrous substance).
CHARACTERS
Appearance: Amorphous, white or almost white powder, hygroscopic.
Solubility: Very soluble in water, soluble in methanol, practically insoluble in methylene chloride.
IDENTIFICATION
A. Thin-layer chromatography.
Test solution: Dissolve 60 mg in 2 ml of water and dilute to 10 ml with methanol.
Reference solution: Dissolve 55 mg of pidolic acid CRS in 2 ml of water and dilute to 10 ml with methanol.
Plate:TLC silica gel plate.
Mobile phase: methanol, glacial acetic acid, methylene chloride (15:20:65 V/V/V).
Application:1 μl.
Development: Over 2/3 of the plate.
Drying: At 100-105C for 15 min.
Detection: Spray with concentrated sodium hypochlorite solution. Allow to stand for 10 min and spray abundantly with glacial acetic acid. Allow to stand again for 10 min and dry the plate at 100-105C for 2 min. Spray with potassium iodide and starch solution until spots appear.
Results: The principal spot in the chromatogram obtained with the test solution is similar in position, colour and size to the principal spot in the chromatogram obtained with the reference solution. The chromatogram obtained with the test solution may show 2 faint secondary spots.
B. To 0.15 ml of solution S (see Tests) add 1.8 ml of water. The solution gives the reaction of magnesium.
TESTS
Solution S: Dissolve 5.00 g in carbon dioxide-free water prepared from distilled water and dilute to 50.0 ml with the same solvent.
Appearance of solution: Solution S is clear and not more intensely coloured than reference solution.
pH: 5.5 to 7.0 for solution S.
Specific optical rotation: - 23.3 to - 26.5 (anhydrous substance), determined on solution S.
Related substances:
Liquid chromatography.
Test solution: Dissolve 0.500 g of the substance to be examined in the mobile phase and dilute to 100.0 ml with the mobile phase.
Reference solution (a): Dilute 1.0 ml of the test solution to 100.0 ml with the mobile phase.
Reference solution (b): Dissolve 50.0 mg pidolate impurity B CRS in the mobile phase and dilute to 100.0 ml with the mobile phase. Dilute 5.0 ml of the solution to 50.0 ml with the mobile phase.
Reference solution (c): Dilute 10.0 ml of reference solution (b) to 100.0 ml with the mobile phase.
Reference solution (d): Dilute 1.0 ml of nitrate standard solution (100 ppm NO3) to 100.0 ml with the mobile phase.
Reference solution (e): Dilute 6.0 ml of reference solution (a) to 10.0 ml with reference solution (b).
Column:
size: = 0.25 m, Dia = 4.6 mm;
stationary phase: octadecylsilyl silica gel for chromatography (5 μm).
Mobile phase: Dissolve 1.56 g of sodium dihydrogen phosphate R in 1000 ml of water R and adjust to pH 2.5 with a 10 per cent V/V solution of phosphoric acid R.
Flow rate: 1.5 ml/min.
Detection: Spectrophotometer at 210 nm.
Injection: 10 μl loop injector; inject the test solution and reference solutions (b), (c), (d) and (e).
Run time: 4 times the retention time of pidolic acid.
Retention times: Pidolic acid = about 4.5 min; impurity B = about 7.5 min.
System suitability: Reference solution (e):resolution: minimum 10 between the peaks due to pidolic acid and to impurity B.
Limits:
impurity B: not more than the area of the principal peak in the chromatogram obtained with reference solution (b) (1.0 per cent);
total of other impurities: not more than half of the area of the principal peak in the chromatogram obtained with reference solution (b) (0.5 per cent);
disregard limit: not more than 0.5 times the area of the principal peak in the chromatogram obtained with reference solution (c) (0.05 per cent); disregard any peak corresponding to the nitrate ion (NO3-).
Impurity A
Thin-layer chromatography.
Test solution: Dissolve 0.250 g of the substance to be examined in 4 ml of water and dilute to 50.0 ml with methanol.
Reference solution (a): Dissolve 60.0 mg of glutamic acid R in 50 ml of water R and dilute to 100.0 ml with methanol. Dilute 1.0 ml of the solution to 20.0 ml with methanol.
Reference solution (b): Dissolve 10 mg of glutamic acid and 10 mg of aspartic acid in water and dilute to 25 ml with the same solvent. Dilute 1 ml of the solution to 10 ml with water.
Plate:TLC silica gel plate R.
Mobile phase: glacial acetic acid, water, butanol (20:20:60 V/V/V).
Application: 5 μl.
Development: Over 2/3 of the plate.
Drying: In air.
Detection: Spray with ninhydrin solution and heat at 100-105C for 15 min.
System suitability: The test is not valid unless the chromatogram obtained with reference solution (b) shows 2 clearly separated spots.
Limit:
impurity A: any spot corresponding to impurity A in the chromatogram obtained with the test solution is not more intense that the spot in the chromatogram obtained with reference solution (a) (0.6 per cent).
Chlorides: Maximum 500 ppm.
Nitrates: Examine the chromatogram obtained with the test solution in the test for related substances.
Limit:
nitrates: not more than the area of the principal peak in the chromatogram obtained with reference solution (d) (200 ppm).
Sulphates: Maximum 0.1 per cent.
Arsenic: Maximum 2 ppm.
Iron: Maximum 200 ppm.
Heavy metals: Maximum 20 ppm.
Water: Maximum 8.0 per cent, determined on 0.200 g.
ASSAY
Dissolve 0.300 g in 50 ml of water. Carry out the complexometric titration of magnesium.
1 ml of 0.1 M sodium EDTA is equivalent to 2.431 mg of Mg.
IMPURITIES
A. glutamic acid,
B. (2S)-2-[[[(2S)-5-oxopyrrolidin-2-yl]carbonyl]amino]pentanedioic acid.
We also supply Magnesium Pidolate EP grade.
Keywords: Magnesium salt of pidolic acid, Pyroglutamic acid, Magnesium Pidolate IP BP Ph Eur EP USP Analytical Reagent FCC Food Grade CAS Number 62003-27-4 Manufacturer Supplier Exporter Monograph Uses Chemical Molecular Formula Weight.
Manufacturers
ANMOL CHEMICALS
Now maturing as Anmol Chemicals Private Limited
Representatives in Houston, Chicago and New York, USA
TEL: (OFF) +91 22 23726950, +91 22 23774610, +91 22 23723564
Taloja Navi Mumbai, INDIA
e-mail: info@anmol.org
Copyright and Usual Disclaimer is Applicable
Last updated
16-aug-24
Exporters to USA, Canada, UAE, Kuwait, Qatar, Gautemala, Tunisia, Europe, South Africa, Bangladesh, Sri Lanka, Tanzania, Kenya, Egypt, Iraq, Turkey, Israel, Vietnam, Nigeria, Uganda, Brazil, Chile, Argentina, Dubai, UAE, Saudi Arabia, Cameroon, Mexico, Brazil, Chile, Argentina, Korea, Thailand, Malaysia, Indonesia, Jakarta, Australia, China, Germany, France, etc.
Representatives in New York, Houston - Texas, Chicago - Illinois, Los Angeles.
All products are Sold for Industrial and Laboratory Use only. No other use is permitted.
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Magnesium Pidolate
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