Anmol Chemicals

Search for the supplies that you need here:

ISO-9001-14001-54001 JK Kosher Halal GMP GLP HACCP FSSAIAllergen freeStar Export India Gluten free
cGMP, GLP - FDA Approved, ISO 9001, ISO 14001, ISO 17025, ISO 45001, HACCP, FSSC 22000, FSSAI, "REACH" Registered, Kosher & Halal Certified. We observe WHO Good Manufacturing Practice GMP and Good Laboratory Practice GLP.

DMF Support Available

WHO GMP
WHO-GMP Certified

Good Manufacturing Practice Certified by World Health Organization
FSCC
FSCC 22000

Food Safety Systems Certification
WC
WC, Written Confirmation

for Active Substance to be imported into European Union (EU).

Home ------ Contact

Chlorobutanol hemihydrate USP NF BP Ph Eur EP Grade Manufacturers

Anmol Chemicals Group, established in 1976, is the pioneer manufacturer of Specialty Chemicals, Pharmaceutical Excipients, Fragrance & Flavor Chemicals in India. Anmol Chemicals Group has manufacturing facilities spread across Western India, representatives in Houston, Chicago USA and Dubai, UAE. We also have toll manufacturing units for processing chemicals in a few countries around the world. We make IP, BP, USP, NF, Ph. Eur., JP, FCC or Food Grade, Analytical Reagent Grade, LR or Laboratory Reagent Grades and Pure Grades of various chemicals. All our items are analyzed to meet the required standards. We can supply the product in grams for your laboratory trial and in tons for your plant scale jobs.

We manufacture Bulk Drugs / API, Excipients, Pharmaceuticals (IP BP USP NF Ph Eur EP JP), Specialty Chemicals (Pure/Reagent), Mineral Fortifiers (FCC). Our manufacturing facility is FDA approved and GLP, cGMP, ISO9001, ISO14001, ISO/IEC 17025, ISO22000, FSSC 22000, ISO45001, FSSAI, Kosher, HALAL, COPP, WHO-GMP certified and Written Confirmation (WC) is available. Solid materials can be customized for particle size, shape, and bulk density. We observe WHO Good Manufacturing Practices and Good Laboratory Practices. We are a government-recognized STAR Export House and "Authorised Economic Operator (AEO)" per Indian Customs.

All technical documents and DMF support available.

Exporter Importer by Sea Exports by Air Chemical Exporter. Palletized for Export. Liquid Products HDPE Drum Packing of Chemicals Bulk Export Packing Jumbo Bag Packing

Chlorobutanol hemihydrate SDS of Manufacturers

Chlorobutanol hemihydrate manufacturers

Synonyms: Chlorobutanol hemihydrate
CAS Number: 57-15-8 and 6001-64-5 for hemihydrate, Molecular Weight: ----, Chemical Formula: C4H7Cl3O and Cl3CC(CH3)2OH-0.5H2O, EINECS EC Number: 200-317-6 and 249-042-3 for hemihydrate, FEMA: 177.45 and 186.46 for hemihydrate,

Chlorbutol or Chlorobutanol has preservative as well as antibacterial and antifungal activity. Apart from other uses, it is used for treatment of impacted ear wax. As a long-term stabilizer of multi-ingredient preparations, chlorobutanol is normally used at a concentration of 0.5%. At this concentration, it also conserves its antimicrobial activity. It is used as is a preservative, sedative, hypnotic and weak local anesthetic.

Chlorobutanol Hemihydrate BP Ph Eur Grade Specifications
C4H7Cl3O,½H2O --- 186.5 --- CAS 6001-64-5
Action and use: Disinfectant preservative.

DEFINITION
1,1,1-Trichloro-2-methylpropan-2-ol hemihydrate.
Content: 98.0 per cent to 101.0 per cent (anhydrous substance).

CHARACTERS
Appearance: White or almost white, crystalline powder or colourless crystals, sublimes readily.
Solubility: Slightly soluble in water, very soluble in ethanol (96 per cent), soluble in glycerol (85 per cent).
Melting point: About 78C (without previous drying).

IDENTIFICATION
A. Add about 20 mg to a mixture of 1 mL of pyridine and 2 mL of strong sodium hydroxide solution. Heat in a water-bath and shake. Allow to stand. The pyridine layer becomes red.
B. Add about 20 mg to 5 mL of ammoniacal silver nitrate solution and warm slightly. A black precipitate is formed.
C. To about 20 mg add 3 mL of 1 M sodium hydroxide and shake to dissolve. Add 5 mL of water and then, slowly, 2 mL of iodinated potassium iodide solution. A yellowish precipitate is formed.
D. Water (see Tests).

TESTS
Solution S: Dissolve 5 g in ethanol (96 per cent) and dilute to 10 mL with the same solvent.
Appearance of solution: Solution S is not more opalescent than reference suspension and not more intensely coloured than reference solution.
Acidity: To 4 mL of solution S add 15 mL of ethanol (96 per cent) and 0.1 mL of bromothymol blue solution. Not more than 1.0 mL of 0.01 M sodium hydroxide is required to change the colour of the indicator to blue.
Chlorides: Maximum 100 ppm.
Water: 4.5 per cent to 5.5 per cent, determined on 0.300 g.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.

ASSAY
Dissolve 0.100 g in 20 mL of ethanol (96 per cent). Add 10 mL of dilute sodium hydroxide solution, heat in a water-bath for 5 min and cool. Add 20 mL of dilute nitric acid, 25.0 mL of 0.1 M silver nitrate and 2 mL of dibutyl phthalate and shake vigorously. Add 2 mL of ferric ammonium sulfate solution and titrate with 0.1 M ammonium thiocyanate until an orange colour is obtained. 1 mL of 0.1 M silver nitrate is equivalent to 5.92 mg of C4H7Cl3O.


Chlorobutanol Hemihydrate EP is also offered.


Specifications of Chlorobutanol USP NF Grade:
C4H7Cl3O (anhydrous) --- 177.46
2-Propanol, 1,1,1-trichloro-2-methyl-.
1,1,1-Trichloro-2-methyl-2-propanol --- CAS 57-15-8.
Hemihydrate --- 186.46 --- CAS 6001-64-5.

Chlorobutanol is anhydrous or contains not more than one-half molecule of water of hydration. It contains not less than 98.0 percent and not more than 100.5 percent of C4H7Cl3O, calculated on the anhydrous basis.
Packaging and storage: Preserve in tight containers.
Labeling: Label it to indicate whether it is anhydrous or hydrous.

Identification:
A: Infrared Absorption.
B: To 5 mL of a freshly prepared solution (1 in 200) add 1 mL of 1 N sodium hydroxide, then slowly add 3 mL of iodine: a yellow precipitate of iodoform, recognizable by its odor, appears.
Reaction: Shake thoroughly 0.5 g with 25 mL of water: the water remains neutral to litmus.
Water: not more than 1.0% (anhydrous form) and not more than 6.0% (hydrous form).
Chloride: To a solution of 0.50 g in a mixture of 25 mL of diluted alcohol and 1 mL of nitric acid add 2 mL of silver nitrate: any turbidity produced is not greater than that produced from a control solution containing 0.50 mL of 0.020 N hydrochloric acid in place of the Chlorobutanol (0.07%).

Assay:
Denatured alcohol: Dilute 100 mL of isopropyl alcohol to 1000 mL with alcohol.
Potassium hydroxide solution: Transfer 58 g of potassium hydroxide to a 1000-mL volumetric flask. Add 100 mL of water to dissolve, then cool the solution. Dilute with Denatured alcohol to volume, and mix. Prepare fresh just prior to use.
Procedure: Transfer about 100 mg of Chlorobutanol, accurately weighed, to a glass-stoppered, flat-bottomed boiling flask. Add 50 mL of Potassium hydroxide solution, attach the flask to a reflux condenser, and reflux for 1 hour. Allow the flask to cool while still attached to the condenser, then add 100 mL of water, using a portion of the water to rinse the condenser and its tip. Add 15 mL of nitric acid while stirring. Titrate with 0.1 N silver nitrate, determining the endpoint potentiometrically, using a silver-billet combination electrode, consisting of a metallic silver indicator electrode and a double junction reference electrode that allows use of a nonchloride filling solution (such as ammonium nitrate solution) for determining chloride, or equivalent. Perform a blank determination and make any necessary correction. Each mL of 0.1 N silver nitrate is equivalent to 5.915 mg of C4H7Cl3O.

Keywords: Chlorobutanol hemihydrate IP BP Ph Eur EP USP Analytical Reagent FCC Food Grade Manufacturer Supplier Exporter Monograph Uses Chemical Molecular Formula Weight.

Logo Star Export India AEO India

Manufacturer Supplier Exporter

ANMOL CHEMICALS
Taloja Mumbai and Ankleshwar, INDIA
Representatives in Houston, Chicago and New York, USA
TEL: (OFF) +91 22 23726950, +91 22 23774610, +91 22 23723564

e-mail: info@anmol.org

Copyright and Usual Disclaimer is Applicable
Last updated 21-sep-22

Calcium Chloride in Jumbo Bags Drum Packing Paletized and Shrink Wrapped Packing for Exports to USA UAE Africa Tanzania Turkey Kenya Dubai

Exporters to USA, Canada, UAE, Europe, South Africa, Tanzania, Kenya, Egypt, Turkey, Nigeria, Uganda, Brazil, Chile, Argentina, Dubai, Cameroon, Mexico, Brazil, Chile, Argentina, Korea, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, etc.

Representatives in New York, Houston - Texas, Chicago - Illinois, Los Angeles.

All products are Sold for Industrial and Laboratory Use only. No other use is permitted.

Fast Selling IP BP Ph Eur EP USP Analytical Reagent FCC Food Grades of Chemicals by Anmol Chemicals
Acetic Acid Glacial --- Aluminum Chloride --- Ammonium bicarbonate --- Ammonium Carbonate --- Ammonium Chloride --- Benzoic Acid --- Benzyl Alcohol --- Boric Acid --- Borax; Sodium Borate --- Calcium Butyrate --- Calcium Chloride --- Calcium Hydroxide --- Calcium Saccharate --- Carbamide Peroxide --- Calcium Oxide --- Calcium Sulfate --- Chromic Chloride --- Copper Sulfate --- Cupric Chloride --- Ferric Chloride --- Fumaric Acid --- Magnesium Butyrate --- Magnesium Chloride --- Magnesium Sulfate --- Malic Acid --- Maleic Acid --- Manganese Chloride --- Manganese Sulfate --- Octyldodecanol --- Oleic acid --- Phenylethyl Alcohol --- Propylene Carbonate --- Potassium Bicarbonate --- Potassium Carbonate --- Potassium Chloride --- Potassium Hydroxide Pellets --- Potassium Alum --- Selenious Acid --- Sodium Acetate --- Sodium Butyrate --- Sodium Chloride --- Sodium Selenite --- Sodium Perborate --- Sodium Hydroxide --- Sodium Sulphate --- Sodium Sulfide --- Sodium Thiosulfate --- Urea --- Zinc Chloride --- Zinc Sulphate ---
Other Best Selling Products
Ammonium Persulfate --- Butylated Hydroxyanisole --- Butylated Hydroxytoluene --- Sodium Bromate --- Sodium Diacetate - Vanadyl Sulfate -

Chlorobutanol hemihydrate
BP Ph Eur EP USP NF Grades Manufacturers
Chlorobutanol hemihydrate