Chlorobutanol hemihydrate BP Ph Eur USP NF JP EP Grade Manufacturers

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Chlorobutanol Hemihydrate USP NF BP Ph Eur EP JP Grade Manufacturers

Anmol Chemicals is a manufacturer supplier exporter of Chlorobutanol Hemihydrate and it offers materials as per IP BP EP Ph Eur USP NF JP FCC Food Grade as per the the latest monograph at best prices. Anmol Chemicals Group, established in 1976, is the pioneer manufacturer of Specialty Chemicals, Pharmaceutical Excipients, Some API, Food Chemicals in India. Anmol Chemicals Group has manufacturing facilities spread across Western India, representatives in Houston, Chicago USA and Dubai, UAE. We also have toll manufacturing units for processing chemicals in a few countries around the world. We make IP, BP, EP, USP, NF, Ph. Eur., JP, FCC or Food Grade, Analytical Reagent Grade, LR or Laboratory Reagent Grades and Pure Grades of various chemicals. All our items are analyzed to meet the required standards. We can supply the product in grams for your laboratory trial and in tons for your plant scale jobs.

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Synonyms: Chlorobutanol hemihydrate
CAS Number: 57-15-8 and 6001-64-5 for hemihydrate, Molecular Weight: ----, Chemical Formula: C4H7Cl3O and Cl3CC(CH3)2OH-0.5H2O, EINECS EC Number: 200-317-6 and 249-042-3 for hemihydrate, FEMA: 177.45 and 186.46 for hemihydrate,

Chlorbutol or Chlorobutanol has preservative as well as antibacterial and antifungal activity. Apart from other uses, it is used for treatment of impacted ear wax. As a long-term stabilizer of multi-ingredient preparations, chlorobutanol is normally used at a concentration of 0.5%. At this concentration, it also conserves its antimicrobial activity. It is used as is a preservative, sedative, hypnotic and weak local anesthetic.

Chlorobutanol Hemihydrate BP Ph Eur Grade Specifications
C4H7Cl3O,½H2O --- 186.5 --- CAS 6001-64-5
Action and use: Disinfectant preservative.

DEFINITION
1,1,1-Trichloro-2-methylpropan-2-ol hemihydrate.
Content: 98.0 per cent to 101.0 per cent (anhydrous substance).

CHARACTERS
Appearance: White or almost white, crystalline powder or colourless crystals, sublimes readily.
Solubility: Slightly soluble in water, very soluble in ethanol (96 per cent), soluble in glycerol (85 per cent).
Melting point: About 78C (without previous drying).

IDENTIFICATION
A. Add about 20 mg to a mixture of 1 mL of pyridine and 2 mL of strong sodium hydroxide solution. Heat in a water-bath and shake. Allow to stand. The pyridine layer becomes red.
B. Add about 20 mg to 5 mL of ammoniacal silver nitrate solution and warm slightly. A black precipitate is formed.
C. To about 20 mg add 3 mL of 1 M sodium hydroxide and shake to dissolve. Add 5 mL of water and then, slowly, 2 mL of iodinated potassium iodide solution. A yellowish precipitate is formed.
D. Water (see Tests).

TESTS
Solution S: Dissolve 5 g in ethanol (96 per cent) and dilute to 10 mL with the same solvent.
Appearance of solution: Solution S is not more opalescent than reference suspension and not more intensely coloured than reference solution.
Acidity: To 4 mL of solution S add 15 mL of ethanol (96 per cent) and 0.1 mL of bromothymol blue solution. Not more than 1.0 mL of 0.01 M sodium hydroxide is required to change the colour of the indicator to blue.
Chlorides: Maximum 100 ppm.
Water: 4.5 per cent to 5.5 per cent, determined on 0.300 g.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.

ASSAY
Dissolve 0.100 g in 20 mL of ethanol (96 per cent). Add 10 mL of dilute sodium hydroxide solution, heat in a water-bath for 5 min and cool. Add 20 mL of dilute nitric acid, 25.0 mL of 0.1 M silver nitrate and 2 mL of dibutyl phthalate and shake vigorously. Add 2 mL of ferric ammonium sulfate solution and titrate with 0.1 M ammonium thiocyanate until an orange colour is obtained. 1 mL of 0.1 M silver nitrate is equivalent to 5.92 mg of C4H7Cl3O.

Specifications of Chlorobutanol USP NF Grade:
C4H7Cl3O (anhydrous) --- 177.46
2-Propanol, 1,1,1-trichloro-2-methyl-.
1,1,1-Trichloro-2-methyl-2-propanol --- CAS 57-15-8.
Hemihydrate --- 186.46 --- CAS 6001-64-5.

Chlorobutanol is anhydrous or contains not more than one-half molecule of water of hydration. It contains not less than 98.0 percent and not more than 100.5 percent of C4H7Cl3O, calculated on the anhydrous basis.
Packaging and storage: Preserve in tight containers.
Labeling: Label it to indicate whether it is anhydrous or hydrous.

Identification:
A: Infrared Absorption.
B: To 5 mL of a freshly prepared solution (1 in 200) add 1 mL of 1 N sodium hydroxide, then slowly add 3 mL of iodine: a yellow precipitate of iodoform, recognizable by its odor, appears.
Reaction: Shake thoroughly 0.5 g with 25 mL of water: the water remains neutral to litmus.
Water: not more than 1.0% (anhydrous form) and not more than 6.0% (hydrous form).
Chloride: To a solution of 0.50 g in a mixture of 25 mL of diluted alcohol and 1 mL of nitric acid add 2 mL of silver nitrate: any turbidity produced is not greater than that produced from a control solution containing 0.50 mL of 0.020 N hydrochloric acid in place of the Chlorobutanol (0.07%).

Assay:
Denatured alcohol: Dilute 100 mL of isopropyl alcohol to 1000 mL with alcohol.
Potassium hydroxide solution: Transfer 58 g of potassium hydroxide to a 1000-mL volumetric flask. Add 100 mL of water to dissolve, then cool the solution. Dilute with Denatured alcohol to volume, and mix. Prepare fresh just prior to use.
Procedure: Transfer about 100 mg of Chlorobutanol, accurately weighed, to a glass-stoppered, flat-bottomed boiling flask. Add 50 mL of Potassium hydroxide solution, attach the flask to a reflux condenser, and reflux for 1 hour. Allow the flask to cool while still attached to the condenser, then add 100 mL of water, using a portion of the water to rinse the condenser and its tip. Add 15 mL of nitric acid while stirring. Titrate with 0.1 N silver nitrate, determining the endpoint potentiometrically, using a silver-billet combination electrode, consisting of a metallic silver indicator electrode and a double junction reference electrode that allows use of a nonchloride filling solution (such as ammonium nitrate solution) for determining chloride, or equivalent. Perform a blank determination and make any necessary correction. Each mL of 0.1 N silver nitrate is equivalent to 5.915 mg of C4H7Cl3O.

Keywords: Chlorobutanol hemihydrate IP BP Ph Eur EP USP Analytical Reagent FCC Food Grade CAS Number 57-15-8 and 6001-64-5 hemihydrate Manufacturer Supplier Exporter Monograph Uses Chemical Molecular Formula Weight.

ANMOL CHEMICALS
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