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Chlorhexidine Gluconate Solution or Chlorhexidine Digluconate Manufacturers
Anmol Chemicals is a manufacturer supplier exporter of Chlorhexidine Gluconate Solution or Chlorhexidine Digluconate and it offers materials as per IP BP EP Ph Eur USP NF JP FCC Food Grade as per the the latest monograph at best prices. Anmol Chemicals Group, established in 1976, is the pioneer manufacturer of Specialty Chemicals, Pharmaceutical Excipients, Some API, Food Chemicals in India. Anmol Chemicals Group has manufacturing facilities spread across Western India, representatives in Houston, Chicago USA and Dubai, UAE. We also have toll manufacturing units for processing chemicals in a few countries around the world. We make IP, BP, EP, USP, NF, Ph. Eur., JP, FCC or Food Grade, Analytical Reagent Grade, LR or Laboratory Reagent Grades and Pure Grades of various chemicals. All our items are analyzed to meet the required standards. We can supply the product in grams for your laboratory trial and in tons for your plant scale jobs.
We manufacture Bulk Drugs / API, Excipients, Pharmaceuticals (IP BP USP NF Ph Eur EP JP), Specialty Chemicals (Pure/Reagent), Mineral Fortifiers (FCC). Our manufacturing facility is FDA approved and GLP, cGMP, ISO9001, ISO14001, ISO/IEC 17025, ISO22000, FSSC 22000, ISO45001, FSSAI, Kosher, HALAL, COPP, WHO-GMP certified and Written Confirmation (WC) is available. Solid materials can be customized for particle size, shape, and bulk density. We observe WHO Good Manufacturing Practices and Good Laboratory Practices. We are a government-recognized STAR Export House and "Authorised Economic Operator (AEO)" per Indian Customs.
All technical documents and DMF support available.
Chlorhexidine Gluconate Solution or Chlorhexidine Digluconate SDS of Manufacturers
Synonyms: Chlorhexidine Gluconate Solution or Chlorhexidine Digluconate
CAS Number: 18472-51-0, Molecular Weight: 897.76, Chemical Formula: C34H54Cl2N10O14, EINECS EC Number: 242-354-0, FEMA: ----,
Chlorhexidine gluconate or CHG, is a disinfectant and antiseptic that is used for skin disinfection before surgery and to sterilize surgical instruments. It is used as a liquid or powder for several pharmaceutical and industrial purpose.
Specifications of Chlorhexidine Gluconate Solution USP Grade:
C22H30Cl2N10-2C6H12O7 --- 897.77
2,4,11,13-Tetraazatetradecanediimidamide, N, N′′-bis(4-chlorophenyl)-3,12-diimino-, di-Dgluconate.
1,1′-Hexamethylenebis[5-(p-chlorophenyl)biguanide] di-D-gluconate CAS 18472-51-0.
Chlorhexidine Gluconate Solution is an aqueous solution of chlorhexidine gluconate. It contains not less than 19.0 percent and not more than 21.0 percent of C22H30Cl2N10-2C6H12O7 (w/v).
Packaging and storage: Preserve in tight containers, protected from light , at controlled room temperature.
Identification:
A: Infrared Absorption: To pass the test.
Recrystallize this solution and dry the crystals at 105 for 1 hour.
B: The crystals obtained in Identification test A melt between 132C and 136C.
C: To 0.05 mL of Solution add 5 mL of a solution of cetyltrimethylammonium bromide (1 in 100), 1 mL of 10 N sodium hydroxide, and 1 mL of bromine: a deep red color is produced.
D: Chromatographic test: To pass the test.
Specific gravity: between 1.06 and 1.07.
pH: between 5.5 and 7.0, when diluted 1 in 20 with water.
Related compounds: To pass the test.
Limit of p-chloroaniline: To pass the test.
Specifications of Chlorhexidine Gluconate Solution BP Ph Eur Grade:
C34H54Cl2N10O14 --- 898 --- CAS 18472-51-0
Action and use: Antiseptic.
DEFINITION
Aqueous solution of 1,1′-(hexane-1,6-diyl)bis[5-(4-chlorophenyl)biguanide] di-d-gluconate.
Content: 190 g/L to 210 g/L.
CHARACTERS
Appearance: Almost colourless or pale-yellowish liquid.
Solubility: Miscible with water, with not more than 3 parts of acetone and with not more than 5 parts of ethanol (96 per cent).
IDENTIFICATION
First identification: A, B
Second identification: B, C, D
A. Infrared absorption spectrophotometry.
B. Thin-layer chromatography. To pass the test.
Results: The principal spot in the chromatogram obtained with the test solution is similar in position, colour and size to the principal spot in the chromatogram obtained with the reference solution.
C. To 1 mL add 40 mL of water, cool in iced water, make alkaline to titan yellow paper by adding dropwise, and with stirring, strong sodium hydroxide solution and add 1 mL in excess. Filter and wash the precipitate with water until the washings are free from alkali and recrystallise from ethanol (70 per cent V/V). Dry at 100C-105C. The residue melts at 132C to 136C.
D. To 0.05 mL add 5 mL of a 10 g/L solution of cetrimide, 1 mL of strong sodium hydroxide solution and 1 mL of bromine water; a deep red colour is produced.
TESTS
Relative density: 1.06 to 1.07.
pH: 5.5 to 7.0.
Dilute 5.0 mL to 100 mL with carbon dioxide-free water.
Impurity P (chloroaniline): Maximum 500 ppm, calculated with reference to chlorhexidine digluconate solution.
Related substances: To pass the test.
ASSAY
Determine the density of the preparation to be examined. Transfer 1.00 g to a 250 mL beaker and add 50 mL of anhydrous acetic acid. Titrate with 0.1 M perchloric acid, determining the end point potentiometrically.
1 mL of 0.1 M perchloric acid is equivalent to 22.44 mg of C34H54Cl2N10O14.
STORAGE
Protected from light.
Typical Specifications of Chlorhexadine Gluconate Solution IP (20 %):
Description: Almost colorless or pale yellowish, clear or slightly opalescent liquid, almost odorless.Solubility: Miscible with water, soluble in ethanol (95%) and in acetone.
Identification:
(a) By Infrared Absorption Spectrophotometry: The infra-red absorption spectrum of the residue is concordant with the reference spectrum of chlorhexidine.
(b) By Thin Layer Chromatography: The principal sport in the chromatogram obtains with solution (1) corresponds to that in the chromatogram obtained with solution (2).
(c) By Chemical Test: A white precipitate is produced which on boiling flocculated and change to a pale purple color.
(d) By Chemical Test: A deep red color is produced.
Relative Density: Between 1.060 and 1.070.
4-Chloroaniline: Not more than 0.25%
Related Substance: By thin-layer chromatography: The absorbance is not more than that obtained with a solution prepared by diluting 2 ml of the substance being examined with sufficient 1.5M acetic acid to produce 10 ml and diluting 0.2 ml of this solution to 50 ml with methanol.
pH: Between 5.5 to 7.0
Assay (By Potentiometric): Not less than 19.0% and not more than 21.0% w/v.
Keywords: Chlorhexidine Gluconate Solution or Chlorhexidine Digluconate IP BP Ph Eur EP USP Analytical Reagent FCC Food Grade CAS Number 18472-51-0 Manufacturer Supplier Exporter Monograph Uses Chemical Molecular Formula Weight.
Manufacturer Supplier Exporter
ANMOL CHEMICALS
Now maturing as Anmol Chemicals Private Limited
Representatives in Houston, Chicago and New York, USA
TEL: (OFF) +91 22 23726950, +91 22 23774610, +91 22 23723564
Taloja Navi Mumbai, INDIA
e-mail: info@anmol.org
Copyright and Usual Disclaimer is Applicable
Last updated
25-feb-24
Exporters to USA, Canada, UAE, Kwait, Qatar, Gautemala, Tunisia, Europe, South Africa, Bangladesh, Sri Lanka, Tanzania, Kenya, Egypt, Iraq, Turkey, Israel, Vietnak, Nigeria, Uganda, Brazil, Chile, Argentina, Dubai, UAE, Saudi Arabia, Cameroon, Mexico, Brazil, Chile, Argentina, Korea, Thailand, Malaysia, Indonesia, Jakarta, Australia, China, Germany, France, etc.
Representatives in New York, Houston - Texas, Chicago - Illinois, Los Angeles.
All products are Sold for Industrial and Laboratory Use only. No other use is permitted.
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Chlorhexidine Gluconate Solution
Chlorhexidine Digluconate IP BP Ph Eur EP USP NF Analytical Reagent FCC Food Grades Manufacturers